Coming SoonPinealon
$79.00A tripeptide from the Khavinson bioregulator lineage that upregulates endogenous antioxidant defenses in cells exposed to oxidative stress.
Molecular studies suggest direct interaction with gene-regulatory regions — a mechanism distinct from receptor-mediated signaling.
Research interest centers on neuroprotection and cellular stress resistance.
Made in USA•Purity: 99% HPLC
- Neuroprotective EffectsIn cell culture, increased neuron survival under oxidative stress and excitotoxic conditions.
- Cognitive PreservationIn aged rodent models, preserved learning and memory performance on behavioral testing paradigms.
- Antioxidant ActivationHas been shown to turn on genes for the body's own antioxidant defenses in neural tissue.
- Proposed DNA InteractionBinding studies suggest the tripeptide may interact with gene promoter regions — an unconventional proposed mechanism.
For in-vitro laboratory research use only. Not for human consumption.
Research Status:Pre-Clinical Studies
Khavinson bioregulation research; cell culture neuroprotection; aged rodent cognitive preservation
For laboratory research use only.
Pinealon is a tripeptide (just three amino acids: Glu-Asp-Arg) that has been shown to protect neurons from oxidative stress and overstimulation damage in cell culture. In aged rodent models, chronic administration preserved learning and memory performance on behavioral testing.
The mechanism is unusual for a peptide this small. Molecular studies suggest Pinealon may interact directly with DNA in gene promoter regions — potentially modulating transcription factor access and gene expression patterns in neural cells. This proposed gene-regulatory action could explain how such a short sequence produces measurable biological effects.
Pinealon was developed through the Khavinson bioregulation research program at the Saint Petersburg Institute of Bioregulation and Gerontology, derived from studies on pineal gland peptide extracts.
Neuroprotective Effects
In cortical neuron and hippocampal cell models exposed to oxidative stress, Pinealon administration increased cell viability and reduced markers of apoptotic cell death. Effects have been characterized alongside stress-responsive gene expression changes. Antioxidant Defense
Pinealon has been associated with upregulation of endogenous antioxidant genes — including superoxide dismutase and glutathione-related enzymes. These transcriptional effects suggest the peptide enhances cellular stress-resistance programs. Cognitive Preservation in Aging
In aged rodent models, chronic Pinealon administration preserved learning and memory on behavioral testing. Improvements correlated with reduced markers of age-related neurodegeneration in hippocampal tissue. Peptide-DNA Binding
Experimental binding studies have characterized Pinealon interaction with specific DNA sequences in gene-regulating regions. The tripeptide appears to attach to DNA in a way that may affect which proteins can access and activate nearby genes.
Pinealon research comes primarily from one research group (Khavinson and colleagues). Independent replication is limited. The peptide-DNA interaction hypothesis, while supported by binding studies, represents an unconventional mechanism that warrants further investigation.
Human clinical data is essentially absent. Effects have been characterized in cell culture and rodent models but not validated in controlled human trials.
| Amino Acid Sequence | Glu-Asp-Arg |
|---|---|
| Single-Letter Code | EDR |
| Molecular Formula | C14H24N6O8 |
| Molecular Weight | 404.37 g/mol |
| Amino Acid Count | 3 |
| CAS Number | 510936-43-3 |
| PubChem CID | 11765407 |
| Origin | Synthetic tripeptide bioregulator derived from Khavinson peptide research on pineal gland extracts, characterized in neuroprotective and cognitive maintenance models |
| Synonyms | EDR peptide, Glu-Asp-Arg, Pineal gland peptide bioregulator |
This product ships as lyophilized (freeze-dried) powder. After reconstitution, the solution requires different storage conditions than the powder.
Reconstituted Solution
Refrigerate2–8°C (36–46°F)Up to 30 daysDo not freeze. Use within 30 days of mixing.
Lyophilized Powder
Refrigerated2–8°C (36–46°F)Weeks to months
Frozen−20°C (−4°F) or belowMonths to years
All peptides are HPLC-purified to ≥99% purity. Each lot includes a Certificate of Analysis (COA) with exact purity percentage, mass spectrometry data, and amino acid analysis.
Lyophilized peptides should be stored at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles.
This product is sold strictly for in-vitro laboratory research purposes only. It is not intended for human consumption and is not a drug, cosmetic, or food product.
Currently we ship within the United States only. International shipping is not available at this time.