N-Acetyl Semax Amidate
10mg | $79.00A stabilized heptapeptide derived from ACTH that increases BDNF — the neurotrophin that supports learning, memory consolidation, and neuronal adaptation — without activating stress-hormone pathways.
The modification (N-acetylation and C-amidation) extends half-life and blocks the adrenocortical effects of the parent fragment.
Research interest centers on cognitive performance under stress and recovery from neurological insult.
Made in USA•Purity: 99% HPLC
- BDNF IncreaseHas been shown to increase BDNF — a protein that helps neurons grow and form new connections. Higher levels correlated with better outcomes in clinical studies.
- Dopamine & SerotoninIncreases dopamine and serotonin activity in attention-related brain regions — without the jittery, hyperactive patterns seen with stimulants.
- Stress Hormone EffectsReduced stress hormone spikes by ~30% in experimental stress models, without suppressing normal baseline function.
- Longitudinal OutcomesIn a 3-year follow-up study, patients showed continued improvement — treated subjects kept improving while controls plateaued.
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For in-vitro laboratory research use only. Not for human consumption.
Research Status:Clinical Studies
Russian clinical trials in stroke recovery; 3-year follow-up showing continued improvement; BDNF biomarker confirmation in 110 patients
For laboratory research use only.
Semax has been studied in stroke recovery — and the results are striking. In a three-year follow-up of patients with reduced cerebral blood flow, those receiving repeated Semax courses showed threefold better functional outcomes than controls. While untreated patients plateaued at 18 months, treated patients kept improving.
The mechanism centers on BDNF — brain-derived neurotrophic factor. A 2018 study of 110 post-stroke patients confirmed that Semax elevates plasma BDNF, and higher BDNF correlated with faster recovery. This connects preclinical neurotrophic findings to a measurable human biomarker.
N-Acetyl Semax Amidate is a stabilized form of Semax with protective caps on both ends — extending half-life in experimental systems. Semax itself derives from ACTH(4-7), a fragment of the stress hormone ACTH. The Pro-Gly-Pro tail was added to eliminate the original hormone's effects on cortisol while preserving neurotrophic activity — keeping the brain benefits without the stress-axis stimulation.
Neurotrophic Signaling
In murine models, Semax upregulates BDNF, NGF, and TrkB in a time- and dose-dependent manner. Effects extend beyond acute administration into sustained receptor-level changes relevant to synaptic consolidation. Transcriptomic Response to Ischemia
Genome-wide profiling in focal ischemia models shows Semax coordinates expression changes across immune response, vascular remodeling, and inflammatory signaling — suggesting neuroprotection through multiple pathways rather than one target.
Optic Neuropathy
Semax has been studied in glaucomatous optic neuropathy, where retinal ganglion cells (which are CNS neurons) showed protection. Patients receiving Semax demonstrated visual field preservation and improved contrast sensitivity — demonstrating that neuroprotective effects extend to retinal neurons.
BDNF Biomarker Confirmation
A 2018 study of 110 post-stroke patients showed Semax elevated plasma BDNF regardless of rehabilitation timing. Higher BDNF correlated with faster functional recovery on standardized measures — bridging preclinical findings to human outcomes. Acute Stroke
Meta-analysis of Russian trials indicates neurological deficits improve more rapidly over the first 10–14 days when Semax is added to standard care. Effects are most pronounced in moderate-to-severe presentations. Functional outcomes improved by day 21. Three-Year Follow-Up
In 120 patients with chronic reduced cerebral blood flow, Semax produced 2.5× greater recovery at one year and 3× at three years. Controls plateaued at ~18 months; treated patients continued improving with repeated courses.
Clinical evidence comes primarily from Russian institutions. The stroke data, while substantial, has limited Western replication. Most studies track weeks to months rather than years.
The N-acetyl amidate modification enhances stability but creates a compound not identical to the Semax in trials — pharmacokinetic equivalence should not be assumed.
- Polunin GS et al. "Semax and BDNF in post-stroke rehabilitation." Zh Nevrol Psikhiatr Im S S Korsakova. 2018. PubMed
- Eremin KO et al. "Semax regulates BDNF and TrkB expression in rat hippocampus." Brain Res. 2006. PubMed
- Potaman VN et al. "Inhibition of enkephalin-degrading enzymes by Semax." Dokl Biochem Biophys. 2001. PubMed
- Ioseliani OR et al. "Effects of Semax on visual function in glaucomatous optic neuropathy." Vestn Oftalmol. 2001. PubMed
For laboratory research use only.
| Amino Acid Sequence | Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 |
|---|---|
| Single-Letter Code | MEHFPGP |
| Molecular Formula | C39H53N9O11S |
| Molecular Weight | 855.97 g/mol |
| Amino Acid Count | 7 |
| CAS Number | 2920938-90-3 |
| Origin | N-acetylated, C-terminal amidated analog of Semax, a synthetic peptide derived from the ACTH(4-7) fragment (Met-Glu-His-Phe) with a C-terminal Pro-Gly-Pro extension |
| Synonyms | N-Acetyl Semax |
This product ships as lyophilized (freeze-dried) powder. After reconstitution, the solution requires different storage conditions than the powder.
Reconstituted Solution
Refrigerate2–8°C (36–46°F)Up to 30 daysDo not freeze. Use within 30 days of mixing.
Lyophilized Powder
Refrigerated2–8°C (36–46°F)Weeks to months
Frozen−20°C (−4°F) or belowMonths to years
All peptides are HPLC-purified to ≥99% purity. Each lot includes a Certificate of Analysis (COA) with exact purity percentage, mass spectrometry data, and amino acid analysis.
Lyophilized peptides should be stored at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles.
This product is sold strictly for in-vitro laboratory research purposes only. It is not intended for human consumption and is not a drug, cosmetic, or food product.
Currently we ship within the United States only. International shipping is not available at this time.