Low StockDSIP
$65.00A nonapeptide originally isolated from cerebral venous blood during sleep that modulates sleep-wake architecture through circadian pathways rather than sedation.
It adjusts cortisol release timing and has antioxidant activity independent of its neural effects — an unusual dual profile.
Research interest centers on sleep quality, stress-axis normalization, and recovery from circadian disruption.
Made in USA•Purity: 99% HPLC
- Sleep ArchitectureHas been shown to increase slow-wave sleep duration while working with circadian rhythms — unlike sedatives that override them.
- Stress Hormone EffectsStudies observed reduced cortisol (the main stress hormone) during challenging conditions.
- Broad NeuromodulationDespite its name, research extends to pain perception, opioid pathway interactions, and antioxidant effects.
- Circadian DependentEffects vary based on timing — works with circadian rhythms rather than overriding them.
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For in-vitro laboratory research use only. Not for human consumption.
Research Status:Pre-Clinical Studies
Discovered 1977; research spans sleep, stress, and antioxidant effects; limited recent investigation
For laboratory research use only.
Despite its name, Delta Sleep-Inducing Peptide does more than promote sleep. In experimental models, DSIP has been shown to buffer stress hormone responses, modulate pain perception, and exhibit antioxidant properties — a broad neuromodulatory profile that extends well beyond sleep architecture.
The peptide was discovered in 1977 when researchers isolated it from the cerebral venous blood of rabbits during electrically induced sleep. Unlike sedatives that force unconsciousness, DSIP appears to modulate sleep-wake cycling — its effects depend on circadian timing rather than simply knocking subjects out.
DSIP is a nonapeptide (nine amino acids) found endogenously in the brain. Research interest centers on its multi-system effects: stress-axis modulation, opioid pathway interactions, and cell-protective properties that operate independently of its sleep-related actions.
Sleep Architecture
Electroencephalographic studies have characterized DSIP as a modulator of sleep-wake cycling. Effects depend on circadian timing of administration — the peptide appears to work with the body's natural rhythms rather than overriding them. Stress Response
In experimental stress models, DSIP has been associated with modulation of the hypothalamic-pituitary-adrenal axis, including altered ACTH and cortisol dynamics. These effects suggest direct hypothalamic actions on stress-responsive neuroendocrine cascades. Cell-Protective Properties
In oxidative stress models, DSIP has been associated with reduced lipid peroxidation and enhanced free radical scavenging enzyme activity. These protective effects have been characterized independently of its neuromodulatory actions — suggesting peripheral tissue benefits beyond the brain.
DSIP is best understood as a legacy/experimental agent with variable outcomes across studies.
DSIP research peaked in the 1980s-1990s, with limited recent investigation. A 1992 study in Pharmacopsychiatry showed only modest increases in sleep efficiency, and results have been inconsistent across trials.
Most studies are preclinical. Human data remains sparse, and the peptide's short half-life in circulation has complicated translation to clinical applications.
The multi-system profile — engaging sleep, stress, pain, and antioxidant pathways — makes mechanism attribution difficult. Effects observed may reflect indirect modulation rather than direct receptor binding.
| Amino Acid Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
|---|---|
| Single-Letter Code | WAGGDASGE |
| Molecular Formula | C35H48N10O15 |
| Molecular Weight | 848.81 g/mol |
| Amino Acid Count | 9 |
| CAS Number | 62568-57-4 |
| PubChem CID | 68816 |
| Origin | Endogenous nonapeptide originally isolated from cerebral venous blood of rabbits during induced sleep, identified as a neuromodulatory factor |
| Synonyms | Delta Sleep-Inducing Peptide, DSIP, Delta sleep peptide |
This product ships as lyophilized (freeze-dried) powder. After reconstitution, the solution requires different storage conditions than the powder.
Reconstituted Solution
Refrigerate2–8°C (36–46°F)Up to 30 daysDo not freeze. Use within 30 days of mixing.
Lyophilized Powder
Refrigerated2–8°C (36–46°F)Weeks to months
Frozen−20°C (−4°F) or belowMonths to years
All peptides are HPLC-purified to ≥99% purity. Each lot includes a Certificate of Analysis (COA) with exact purity percentage, mass spectrometry data, and amino acid analysis.
Lyophilized peptides should be stored at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles.
This product is sold strictly for in-vitro laboratory research purposes only. It is not intended for human consumption and is not a drug, cosmetic, or food product.
Currently we ship within the United States only. International shipping is not available at this time.